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Chemicals 5-fluorouracil cas 51-21-8
Chemicals 5-fluorouracil cas 51-21-8
Chemicals 5-fluorouracil cas 51-21-8
Chemicals 5-fluorouracil cas 51-21-8

Chemicals 5-fluorouracil cas 51-21-8

Payment Type: L/C,T/T,Money Gram,Western Union
Incoterm: FOB,CIF
Min. Order: 1 Kilogram
Delivery Time: 3 Days

Basic Info

    Model No.: X-CAS 51-21-8

    Name:: 5-fluorouracil

    CAS:: 51-21-8

    MF:: C4H3FN2O2

    MW:: 130.07700

    Exact Mass:: 130.01800

    Density:: 1.53 G/cm3

    MP:: 282-286 °C (dec.)(lit.)

    Bp:: 190-200°C/0.1mmHg

    FP:: 196.5ºC

Additional Info

    Packaging: 1kg/bottle; 25kg/drum; 160kg/plastic drum

    Productivity: 1000kg per Month

    Brand: zhishang

    Transportation: Ocean,Land,Air

    Place of Origin: Shandong, China (Mainland)

    Supply Ability: in stock

    Certificate: ISO CE

    HS Code: 2933599090

    Port: Shanghai,Qingdao,Tianjing

Product Description

Chemicals 5-fluorouracil cas 51-21-8

The use of methotrexate prior to 5-fluorouracil increases the formation of 5-fluorouracil nucleotides by increasing the content of intracellular phosphoribosyl pyrophosphate. Allopurinol alters the effects of fluorouracil, its metabolite, allopurinol, and inhibits orotate phosphoribosyltransferase, thus reducing toxicity and potentially improving the therapeutic index. Thymidine and other nucleosides increase the binding of fluorouracil to RNA, which can delay the breakdown of fluorouracil by dihydropyrimidine dehydrogenase. However, this combination has so far failed to significantly improve the clinical outcome.

Other categories: Active Pharmaceutical Ingredients(API); Fragrance And Spices ; Pharmaceutical Intermediates ; Organic Raw Material ; Daily Chemicals ; Dyestuffs And Pigments ; Chinese Herb Extracts; As Acid Dyes; Stabilizer Of Plastic Products ; Agricultural Chemicals; Chemicals Used In Paints; Isophthaloyl Dichloride ; Trichloroacetic Acid ; Inorganic Salt ; Magnesium Sulphate ; Sodium Hexametaphosphate ; Api Clomipramine; Api Baclofen Powder; Organic Synthetic Raw Material ...

Product Analysis

Items

Appearance

Specifications

White to off-white crystalline powder

Results

Conform

Identification

A. IR

Conform

B. UV

Conform

C. HPLC

Conform

Loss on drying

≤0.5%

0.06%

Residue on ignition

≤0.1%

0.03%

Heavy metals

≤20ppm

Conform

Impurities F and Urea

(TLC method)

Impurity F≤0.25%

Conform

Urea≤0.20%

Conform

Related substance

(HPLC method)

Impurity A≤0.25%

<0.01% (LOD)

Impurity B≤0.25%

<0.01% (LOD)

Uracil≤0.15%

<0.01% (LOD)

5-Methoxyuracil≤0.15%

0.08%

Impurity E≤0.25%

<0.01% (LOD)

Any individual unspecified impurity

≤0.10%

Each<0.05%

(disregard limit)

Total≤0.5%

0.08%

Assay (HPLC method)

98.0-102.0%

99.6%

Bacterial endotomin

≤0.25 EU/mg

Conform

Mould and yeast count

≤100 cfu/g

Conform

Aerobic microbial count

≤1000 cfu/g

Conform

Escherichia coli

Absent/g

Absent/g

Pseudomonas aeruginosa

Absent/g

Absent/g

Staphylococcus aureus

Absent/g

Absent/g

Conclusion

The product meets the requirements of USP 37


Function and Application

5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

Product expansion

1> Cosmetic Raw Materials : Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories. The former is a class of cosmetics in the main raw materials, cosmetics in the possession of a large proportion of the cosmetics play a major role in the role of the material. The latter is the formation of cosmetics, stability or to give color, smell and other characteristics of the role of these substances in the cosmetic formula is not used, but it is extremely important. Cosmetics are natural, synthetic or extracted from the role of different substances as raw materials, by heating, mixing and emulsification and other production processes processed from the chemical mixture.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.It is one substance or mixture during the medicine making period uut it can not be taken directly by patients.

3> Fragrance And Spices: Spice is a substance that can be scented by smelling or scented by taste, and is the raw material for the preparation of the fragrance. Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, pesticides, pharmaceuticals, resins, Additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion, usually in resin, or oil, or emulsion is given priority to, add or not add pigment, filler, add the corresponding additives, organic solvents or water preparation of viscous liquid.

Certification

We strictly complying with ISO9001 and ISO 2000 standard in manufacturing process, our lab and workshop tightly in accordance with GMP standard.

Our Advantage

1.Stable quality, high quality satisfy customer's high grade sourcing request.

2.Competitive price .

3.Correct delivery time promise.

4.Continuous improvement make sure the long-term cooperation.

5.Honest service for your whole sourcing process

Services

1.Cooperate with research institutions, we strictly control the process from raw material to finished product.

2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.

3.We can send the goods to your delivery address directly. It is relatively safe and fast. We have ready goods in stock.
4.Quick and clear response to customers questions.
5.Warm after sale service, we will help to solve the problems in your usage.
5.We could make our price discount if you place a substantial order with us.



5 Chemicals 5-fluorouracil cas 51-21-8q7 Chemicals 5-fluorouracil cas 51-21-8



Looking for ideal MF is C4H3FN2O2 Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Name of Efudix are quality guaranteed. We are China Origin Factory of Fluri or 5-fluoro-uracile. If you have any question, please feel free to contact us.

Product Categories : Organic Intermediate > Pharmaceutical Intermediates

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Wang Dongjun

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