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Home > Products > Organic Intermediate > Pharmaceutical Intermediates > 2-Chloronicotinic acid CAS NO 2942-59-8

2-Chloronicotinic acid CAS NO 2942-59-8
2-Chloronicotinic acid CAS NO 2942-59-8
2-Chloronicotinic acid CAS NO 2942-59-8
2-Chloronicotinic acid CAS NO 2942-59-8

2-Chloronicotinic acid CAS NO 2942-59-8

Payment Type: L/C,T/T,Money Gram,Western Union
Incoterm: FOB,CIF
Min. Order: 1 Kilogram
Delivery Time: 3 Days

Basic Info

    Model No.: CAS 2942-59-8

    MF: C6H4ClNO2

    Purity:: 99% Min

    Appearance:: Colourless Liquid

    CAS No.:: 2942-59-8

    MP: 176-178 °C (dec.)(lit.)

    BP: 316.8ºC At 760 MmHg

    Density: 1.47 G/cm3

Additional Info

    Packaging: 25kg/ DRUM,according to customers' requirements

    Productivity: 1000kg per Month

    Brand: zhishang

    Transportation: Ocean,Land,Air

    Place of Origin: Shandong, China (Mainland)

    Supply Ability: in stock

    Certificate: ISO CE

    HS Code: 2942-59-8

    Port: Shanghai,Tianjin,Qingdao

Product Description

Description

The preparation of the following two.
(1) 3-methylpyridine as Raw Material , the first reaction with hydrogen peroxide to generate N-oxo-3-methylpyridine, and then in the presence of acid binding agent diisopropylamine in the solvent was added dropwise trichlorooxy Chlorination of phosphorus as the chlorinating agent gives a mixture of 2-chloro-5-methylpyridine and 2-chloro-3-methylpyridine using a separation technique combining crystallization and rectification to give 2-chloro -5-methylpyridine and 2-chloro-3-methylpyridine. Chlorination of 2-chloro-3-methylpyridine gives 2-chloro-3-trichloromethylpyridine. Further hydrolysis gives 2-chloro-3-pyridinecarboxylic acid chloride or 2-chloro-3-pyridinecarboxylic acid (2-chloronicotinic acid).
(2) Chlorine gas is introduced into the mixture of phosphorus oxychloride and phosphorus trichloride, and the temperature is controlled at about 60 DEG C until residual chlorine gas escapes. The nicotinic acid N-oxide is cooled and added in batches, heated and mixed Liquid in. 100 ~ 105 ℃ reaction 1 ~ 1.5h, until the reaction mixture was stirred for 30min after the reaction was transparent, and the phosphorus oxychloride was removed under reduced pressure, the resulting residue was cooled to room temperature, add water to obtain the finished product.



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Product expansion

1> Cosmetic Raw Materials: Cosmetics is a variety of raw materials through a reasonable deployment of processing from the compound mixture. Cosmetics with a wide range of raw materials, different performance. According to the Raw Material properties and uses of cosmetics, can be divided into matrix materials and auxiliary raw materials in two categories.

2> Active Pharmaceutical Ingredients(API): API refers to the raw materials in the production of various types of preparations, which is the active ingredient in powder,crystal and paste for medicine use through chemical synthesis,plant extract, and preparations of biotechnology institute.

3> Fragrance And Spices: Spices are an important part of fine chemicals, it is composed of natural spices, synthetic spices and single fragrance.

4> Organic Raw Material: Intermediates are also known as organic intermediates. The use of coal tar or petroleum products as raw materials to produce dyes, resins, Additives, and other intermediates.

5> Chemicals Used In Paints: Paint, the traditional Chinese name is paint. So-called coating is coated on the surface of the object that be protected or be adornment, and with the continuous film coating to form strong adhesion.

6> Pharmaceutical Intermediates: The so-called pharmaceutical intermediates, refers to the production of pharmaceutical products in the process, the use of raw materials, materials, accessories and other intermediate products.

7> Agricultural Chemicals: Research and agriculture related chemical, including pesticide, plant growth regulator, fertilizer, compound fertilizer, herbicide etc.


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